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. 2019 Jul 28;9(19):5532–5541. doi: 10.7150/thno.34070

Figure 3.

Figure 3

The mutation detection of cytological negative PE and hemorrhagic PE. A) Cytological inspection of cells in pleural effusion. For each pleural effusion sample, a haemotoxylin and eosin (H&E) stained cell smear was observed under the microscope at 400× magnification. Tumor cell(-): samples without tumor cells; tumor cell(+): samples with tumor cells. B) Mutation spectra of PE-cfDNA and sDNA from six tumor cell(-) PE samples. C) In cohort 1, the sensitivities of detecting tissue-determined mutations in PE-cfDNA and sDNA from tumor cell(+) or tumor cell(-) pleural effusion. The Chi-square test was used to compare the sensitivity between tumor cell(+) and tumor cell(-) samples. D) In cohort 1, the sensitivities of detecting tissue-determined mutations in PE-cfDNA and sDNA from hemorrhagic or clear pleural effusion. ***, p < 0.001.