Figure 8.
Dual-model imaging and in vivo biodistribution. (A) PA signal in vitro. PA signal intensity of Au-Apt-TPE@Zn with different concentrations (1.25, 2.5, 5, 10, 15, 20 and 30 µg/mL) was monitored. (B) Real-time PA images in vivo. PA signal of tumor in vivo was monitored at different time points. (C) Real-time fluorescence imaging in vivo. In vivo bioluminescence imaging of the mice was examined at different time points. (D-E) MR images. T2-weighted MRI was employed to evaluate the photothermal therapy against SGC-7901 human gastric carcinoma xenograft growth. Red arrows indicated the tumor area. Au-Apt-TPE@Zn (2 mg/kg) was administrated intravenously for all mice.