Figure 3.

In vitro toxicity and DNA damage achieved by ¹¹¹In-EGF-LP-Dox. Clonogenic studies of (A) MDA-MB-468 and (B) MCF7 cells following a 24 h treatment and 14 days incubation. (n = 3, standard deviation shown). Statistical analysis was performed using ANOVA with Bonferroni analysis. For each concentration, significant differences between each group are represented, the other comparison were non-significant (* = p < 0.05; ** = p < 0.005 and *** = p < 0.0005). (C) DNA damage studies for MDA-MB-468 and MCF7 after treatment with liposomal formulations. Number of γH2AX foci/cell counted using ImageJ software. Incubation for 24 h at 37 °C (n = 3, standard deviation shown **** = p<0.00005, *** = p<0.0005 and ** = p<0.005 using ANOVA with Fisher's LSD analysis), supporting images can be found in SI on Figure S7.