Figure 1.

Schematic representation of exosomes expressing 10E8 single chain fragment and targeting Env⁺ cells.(A)HEK293T cells were transfected with a plasmid containing the recombinant 10E8_scFv-pDisplay. The 10E8_scFv-expressing exosomes were loaded with Cur to generate Cur-containing 10E8_scFv-exosomes or transfected with miR-143 in order to generate miRNA-containing 10E8_scFv-exosomes. The efficacy of engineered exosomes was tested in vitro and in vivo on Env⁺ cells. (B) Schematic representation of the pDisplay plasmid construct containing scFv of 10E8 monoclonal antibody.