Figure 1.

Function of ETV2. (A) In early embryogenesis, ETV2 plays indispensable roles for the establishment of the cardiovascular system through the direct binding to promoters or enhancers of genes critical for the hematopoietic and endothelial cell lineages. Recent reports suggest that ETV2 can form an active transcriptional complex at least with OVOL2, GATA2, FOXC2 or TET1/2. (B) In post-natal life, ETV2 regulates the proliferation of bone marrow (BM) hematopoietic stem cells. In addition, ETV2 robustly promotes new vessel formation in pathophysiological conditions such as injury, MI, and tumorigenesis. (C) ETV2 alone or in combination with other TFs or small molecules can directly reprogram non-endothelial cells into cells displaying endothelial functionalities.