FIGURE 4.

COX2 expression in (A) kidney and (B) muscle homogenates at 6 hours post-pFUS. COX2 expression increased when pFUS is administered to muscle or kidney of mice that receive no drugs. COX2 expression following pFUS was suppressed in wild-type mice that received intravenous GdCl₃ (300 μg/kg), Ruthenium Red (RR; 22 mg/kg), or intraperitoneal verapamil (5 mg/kg) prior to pFUS and untreated TRPC1-KO mice (n=6 mice per group; separate cohorts were used for muscle and kidney treatments) (* p<0.05 by ANOVA). For presentation, control samples represent values from unsonicated tissues in mice that received no drugs or TRPC1-ko. These values were not significantly different from unsonicated tissues in mice that received drugs or TRPC1-ko (See Supplemental Data).