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. 2019 Sep 5;5(11):e192553. doi: 10.1001/jamaoncol.2019.2553

Figure 2. Kaplan-Meier Curves of Study Outcomes for Comparison Between Therapy With EGFR-TKIs vs EGFR-TKIs Plus Metformin.

Figure 2.

A, Median progression-free survival is 9.9 (95% CI, 7.5-12.2) months for EGFR-TKIs vs 13.1 (95% CI, 9.8-16.3) months for EGFR-TKIs plus metformin (HR, 0.60; 95% CI, 0.40-0.94; P = .03). B, Median progression-free survival is 9.7 (95% CI, 5.1-14.3) months for EGFR-TKIs vs 11.8 (7.3-20.6) months for EGFR-TKIs plus metformin (HR, 0.64; 95% CI, 0.41-0.99; P = .049). C, Median objective response rate is 54.3% (38 of 70) for EGFR-TKIs vs 71.0% (49 of 69) for EGFR-TKIs plus metformin (P = .04). D, Median overall survival is 17.5 (95% CI, 11.4-23.7) months for EGFR-TKIs vs 31.7 (95% CI, 20.5-42.8) months for EGFR-TKIs plus metformin (HR, 0.50; 95% CI, 0.28-0.90; P = .02). EGFR-TKIs indicates epidermal growth factor receptor–tyrosine kinase inhibitors; HR, hazard ratio; and RECIST, Response Evaluation Criteria in Solid Tumors guideline (version 1.1).