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Representation, on the left, of the X-ray crystal structure for HsOMPDC liganded by UMP (PDB entry 2QCD) and, on the right, for ScOMPDC liganded by 6-azaUMP (PDB entry 3GDL). There is good superposition between the active site residues D312, K314, and D317 at HsOMPDC with D91, K93, and D96 at ScOMPDC, and of the hydrophobic side chains F310, I401, and I448 at the CO2 binding pocket with F89, I183 and I232.
