NCT00857662.

Trial name or title	US multicenter, randomized controlled study comparing the performance of Onyx(EVOH) and TRUFILL® (n‐BCA) in presurgical embolization of brain arteriovenous malformations (BAVMs)
Methods	Multicentre, prospective, randomized, controlled, open label, clinical trial
Participants	Patients of any age, diagnosed with a brain AVM (with a Spetzler‐Martin grade of I, II, III, or IV) and the patient is a candidate for surgical resection of the AVM post embolization
Interventions	Onyx (investigational device) versus TRUFILL (control device) in the presurgical embolization of brain AVMs
Outcomes	Primary outcome measures angiographic reduction in AVM size (volume) of 50% or greater, where angiographic size reduction is defined as the change from the original AVM size prior to any embolization procedure, to the AVM size after the last embolization Secondary outcome measures Safety will be assessed by the nature and severity of adverse events Surgical blood loss Surgical resection time
Starting date	May 2001
Contact information	Gary Duckwiler MD
Notes	Sponsor: Medtronic Neurovascular Clinical Affairs