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. 2019 Aug 14;9(21):6314–6333. doi: 10.7150/thno.36252

Figure 5.

Figure 5

Fluorescence images of 4T1 cells stained by a Live/Dead viability/cytotoxicity kit after various treatments, including (A) blank control, (B) H2O2, (C) NIR laser, (D) DOX; (E) ICG plus laser, (F) SMID, (G) SMID plus laser, (H) SMID plus laser and H2O2 (equivalent ICG concentration: 16 µg·mL-1; H2O2: 100 µM; laser irradiation: 5 min). The dashed circles denote the laser irradiation spots (scale bars: 200 µm). The green and red dots represent live and dead cells, respectively. (I) Viability of HUVECs and L929 cells after treatment with SF@MnO2 nanoparticles at various concentrations for 24 h. (J) Viability of 4T1 cells after various treatments (“L” indicates the NIR laser irradiation for 5 min, “H” denotes H2O2 at 100 µM).