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. 2019 Aug 14;9(21):6080–6098. doi: 10.7150/thno.36514

Figure 6.

Figure 6

In vivo behaviours of the Herceptin-loaded mixture-A hydrogel. (A) Real-time in vivo fluorescent imaging of SK-BR-3 tumor-bearing nude mice with hypodermic injection of Cy5.5-Her solution or the Cy5.5-Her-loaded mixture-A hydrogel. The fluorescence intensity of Cy5.5-Her in the hydrogel was 4 times greater than that of Cy5.5-Her solution; however, the Cy5.5-Her solution was injected into the mice once per week for 4 weeks, and the Cy5.5-Her-loaded hydrogel was injected only once. Therefore, the total amount of Cy5.5-Her in the two groups was equal. All the images shown in the same group are from the same mouse. (B) Semiquantitative analysis of the fluorescence signals at the injection sites as a function of time. The first injection time was defined as day 0. (C) Ex vivo fluorescent imaging of the major organs and tumors harvested from the mice on day 28 post-treatment. (D) Semiquantitative analysis of the fluorescence signals in tumors on day 28 post-treatment.