Figure 4.
NanoTLZ is better tolerated than free Talazoparib in BRCA-deficient mice. A. Brca1Co/Co;MMTV-Cre;p53+/- mice were treated three times a week and weighed prior to each treatment. Initial weight, the weight when the mice were started on treatment; final weight, weight after 10 injections of the corresponding treatment. Data presented as mean ± SEM. N=5 in saline group and N=8 in the NanoTLZ and Talazoparib treatment groups (i.v. TLZ and oral TLZ). *, p<0.05 vs. initial weight. B. Representative pictures of alopecia observed in free Talazoparib treatment groups.