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. 2019 Aug 14;9(21):6224–6238. doi: 10.7150/thno.36281

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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NanoTLZ modulates immune cell populations in BRCA-deficient mice. Brca1^Co/Co;MMTV-Cre;p53^+/- mice bearing tumors (4 mm in diameter) were treated with 5 doses of saline, empty nanoparticle (vehicle), free TLZ (i.v. TLZ) or NanoTLZ, and tumor, spleen and mammary gland without visible tumors were collected for flow cytometry. The percentage of immune populations with significant changes in spleen, mammary gland, or tumor are shown from A to C, respectively. N=5 mice/group. *, p<0.05 vs. saline. D. The changes of total immune cells (CD45) and T cells (CD3) in mammary gland were confirmed by immunohistochemistry. The changes in myeloid-derived suppressor cells (MDSCs, Gr-1) in the spleen were also validated using immunohistochemistry, 200x magnification. The change of Foxp3 expression around the tumor was shown by IHC at 400x magnification.