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. 2019 Aug 14;9(21):6300–6313. doi: 10.7150/thno.36120

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The relative genes expression in chondrocytes treated with different concentrations of Cu²⁺ ions for 3 days. (A) COL II, (B) ACAN, (C) SOX-9, (D) HIF-1α. After treating with different concentrations of Cu²⁺ ions, the relative genes of chondrocytes were significantly enhanced. The relative gene amount of CTR group was set as 1. (n=3, *p<0.05, **p<0.01, ***p<0.001)