Table 2.
Significant tissue-pathways enrichment analysis using Reactome database.
| Tissue | Pathway | pval | padj | ES | NES | Genes | |
|---|---|---|---|---|---|---|---|
| Colon sigmoid | Immune system | 3.8E–04 | 1.2E–02 | –5.4E–01 | –2.3E+00 | CAP1 RASGRP4 RASGRP4 YES1 SIGLEC8 CD47 SELL CALM1 |
FBXO21 CLEC7A CLEC7A SEC61A1 IL13 HLA-DPB1 KIF11 |
| Brain nucleus | Generic transcription pathway | 3.0E–03 | 1.8E–02 | 7.2E–01 | 2.1E+00 | ZNF688 ZKSCAN8 ZNF445 |
RRAGC ZNF697 CASP6 |
| Brain nucleus | RNA polymerase II transcription | 3.0E–03 | 1.8E–02 | 7.2E–01 | 2.1E+00 | ZNF688 ZKSCAN8 ZNF445 |
RRAGC ZNF697 CASP6 |
| Brain nucleus | Gene expression (transcription) | 3.0E–03 | 1.8E–02 | 7.2E–01 | 2.1E+00 | ZNF688 ZKSCAN8 ZNF445 |
RRAGC ZNF697 CASP6 |
| Colon sigmoid | Adaptive immune system | 3.0Ev03 | 3.3E–02 | –6.1E–01 | –2.1E+00 | FBXO21 SEC61A1 HLA-DPB1 KIF11 |
YES1 SIGLEC8 SELL CALM1 |
| Colon sigmoid | Innate immune system | 2.5E–03 | 3.3E–02 | –6.5E–01 | –2.0E+00 | CAP1 CLEC7A CD47 CALM1 |
RASGRP4 YES1 SELL |