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. 2019 Sep 6;12:1773–1781. doi: 10.2147/DMSO.S211253

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© 2019 Rangel Silvares et al.

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Kidney endothelial function of control group (CTL), HFD-induced MetS rats (HFD/MetS) and MetS rats treated with 60 mg/kg/day pyridoxamine (PM) during the last 8 weeks of HFD feeding. Laser speckle contrast imaging (LSCI) assessment of basal microvascular flux (A and C, 20 and 28 weeks of HFD, respectively) and percentage (%) of change in kidney microvascular flux after topic acetylcholine (Ach) administration (B and D, 20 and 28 weeks of HFD, respectively). Real-time PCR analyses of mRNA transcript levels of genes coding for eNOS (E) and VCAM (F). **P<0.001, ***P<0.001 vs control and P<0.001 vs HFD/MetS.

Abbreviations: ach, acetylcholine; CTL, control; HFD, high-fat diet; LSCI, laser speckle contrast imaging; MetS, metabolic syndrome; PM, pyridoxamine.