Table 6.
Gene Polymorphisms of Contacts of Pulmonary TB Cases Evaluated for Development of Active TB Infection
| SNP | Active TB n = 44 |
No Active TB n = 482 |
OR | 95% CI | P-Value | ||
|---|---|---|---|---|---|---|---|
| rs5743708–TLR2 | 8 | (23.5) | 62 | (15.5) | 1.7 | (0.7–3.9) | .2 |
| rs4986791–TLR4 | 5 | (14.7) | 9 | (2.3) | 7.3 | (2.3–23.2) | <.01 |
| rs361525–TNFA | 23 | (52.3) | 51 | (10.7) | 9.0 | (4.7–17.7) | <.01 |
| rs2430561–IFNG | 25 | (78.1) | 310 | (83.3) | 0.7 | (0.3–1.7) | .5 |
| rs1143627–IL1B | 17 | (44.7) | 208 | (47.2) | 0.9 | (0.5–1.8) | .8 |
Data represent no. (%).
Abbreviations: CI, confidence interval; IFNG, interferon gamma; IL1B, interleukin-1β; OR, odds ratio; SNP, single-nucleotide polymorphism; TLR, Toll-like receptor; TNFA, tumor necrosis factor α.