Figure 4.

CXCR4 expression on non-classical monocytes correlates with traditional cardiovascular and HIV-related clinical risk factors. Spearman’s rank correlation analysis was performed to evaluate correlations of CXCR4 expression on non-classical monocytes with cardiovascular and HIV-related risk factors among the whole cohort. Values are presented as Spearman’s rank correlation coefficient r. CXCR4 expression on non-classical monocytes is (A) negatively correlated with systolic blood pressure (BPsys, r = −0.212, P = 0.042) and (B) blood platelet count (r = −0.277, P = 0.022) and (C) positively correlated with left ventricular mass (r = 0.268, P = 0.038), (D) the duration of ART (r = 0.338, P = 0.022) and (E) HAART (r = 0.307, P = 0.038 in HIV+ subjects) as well as with (F) blood CD4 T cell counts (CD3CD4 r = 0.270, P = 0.024) and (G) the CD4 to CD8 T cell ratio (r = 0.299, P = 0.044). CXCR4 on non-classical monocytes was negatively correlated with (H) the blood CD8 T cell count (CD3CD8, r = −0.295, P = 0.013) and with (I, J) apoptotic T cells [as detected by activated caspase-3, (I) CD4 Casp3 r = −0.547, P = 0.001, (J) CD8 Casp3 r = −0.326, P = 0.006]. There was no significant correlation of CXCR4 expression on non-classical monocytes with other cardiovascular risk factors as (K) hsCRP (r = −0.096, P = 0.361), (L) Framingham risk score (r = −0.152, P = 0.148), (M) total cholesterol (r = −0.105, P = 0.364), (N) LDL (r = −0.171, P = 0.147), (O) HDL (r = −0.009, P = 0.941),