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. 2019 May 4;24(6):383–394. doi: 10.1093/pch/pxz036
Rome II (1999–2006)* Rome III (2006–2016)
IBS In children old enough to provide an accurate pain history, at least 12 weeks, which need not be consecutive, in the preceding 12 months of;
(1) Abdominal discomfort or pain that has
two out of three features:
(a) Relieved with defecation; and/or
(b) Onset associated with a change in
frequency of stool; and/or
(c) Onset associated with a change in
form (appearance) of stool; and
(2) There are no structural or metabolic abnormalities to explain the symptoms.		 Must include all of the following:
1. Abdominal discomfort (an uncomfortable sensation not described as pain) or pain associated
with 2 or more of the following at least 25% of
the time:
a. Improved with defecation
b. Onset associated with a change in frequency
of stool
c. Onset associated with a change in form (appearance) of stool
2. No evidence of an inflammatory, anatomic,
metabolic, or neoplastic process that explains
the subject’s symptoms
*Criteria fulfilled at least once per week for at least 2 months before diagnosis
FAP At least 12 weeks of:(1) Continuous or nearly continuous abdominal pain in a school-aged child or adolescent; and
(2) No or only occasional relation of pain
with physiological events (e.g., eating, menses, or defecation); and
(3) Some loss of daily functioning; and
(4) The pain is not feigned (e.g., malingering);and
(5) The patient has insufficient criteria for other functional gastrointestinal disorders that would explain the abdominal pain.		 Must include all of the following:
1. Episodic or continuous abdominal pain
2. Insufficient criteria for other FGIDs
3. No evidence of an inflammatory, anatomic,
metabolic, or neoplastic process that explains
the subject’s symptoms
*Criteria fulfilled at least once per week for at least 2 months before diagnosis
FD In children old enough to provide an accurate pain history, at least 12 weeks, which need not be consecutive, in the preceding 12 months of;
(1) Persistent or recurrent pain or discomfort centered in the upper abdomen (above the umbilicus)
(2) No evidence of organic disease (including at upper endoscopy) that is likely to explain the symptoms; and
(3) No evidence that dyspepsia is exclusively relieved by defecation or associated with onset of a change ins tool frequency or stool form (i.e., not irritable bowel)		 Must include all of the following:
1. Persistent or recurrent pain or discomfort centered in the upper abdomen (above the umbilicus)
2. Not relieved by defecation or associated with the onset of a change in stool frequency or stool form (i.e., not irritable bowel syndrome)
3. No evidence of an inflammatory, anatomic, metabolic or neoplastic process that explains the subject’s symptoms
*Criteria fulfilled at least once per week for at least 2 months prior to diagnosis

*Rome IV has been adopted since 2016 (6). No included studies reported Rome IV results.