Figure 1.
Oxyclozanide enhances aminoglycosides and tetracycline. Biofilms (24 h old) were treated for 6 h with oxyclozanide (100 μM), tobramycin (500 μM), gentamicin (100 μM), streptomycin (100 μM) or tetracycline (100 μM), alone and in combination, and the number of viable cells within the biofilms was quantified by BacTiter-GloTM. The assay was performed at least three times in triplicate. The results represent means plus the SEM. A one-way ANOVA followed by Bonferroni’s multiple comparison post hoc test was used to determine statistical significance between the combination and each antibiotic alone (*P < 0.05).