Figure 5.
Oxyclozanide accelerates tobramycin killing of P. aeruginosa biofilms. Twenty-four hour biofilms were treated with oxyclozanide (100 μM) or tobramycin (500 μM), alone and in combination. At 0, 2, 4, 6, and 8 h, the number of viable cells within the biofilms was determined by BacTiter-GloTM. The assay was performed at least three times in triplicate. The results represent means ± SEM. A one-way ANOVA followed by Bonferroni’s multiple comparison post hoc test was used to determine statistical significance between the combination and tobramycin alone (*P < 0.05).