Table 2.
RRs and APs Due to Interaction With 95% CIs in Relation to LADA for Different Combinations of BMI and Genotypes of HLA, TCF7L2, and FTO
| BMI Categories | Genotypes | ESTRID | HUNT | Pooled | ||||
|---|---|---|---|---|---|---|---|---|
| Cases (n) | Controls (n) | RR (95% CI) | Cases (n) | Person-Years | RR (95% CI) | RR (95% CI) | ||
| BMI ≥ 25 | HLA high risk | |||||||
| − | − | 42 | 637 | 1 (Reference) | 8 | 251,825 | 1 (Reference) | 1 (Reference) |
| + | − | 111 | 587 | 2.57 (1.69–3.92) | 44 | 258,428 | 3.86 (1.81–8.26) | 2.83 (1.96–4.09) |
| – | + | 76 | 325 | 3.84 (2.43–6.05) | 15 | 186,239 | 2.55 (1.08–6.01) | 3.51 (2.35–5.25) |
| + | + | 165 | 277 | 7.56 (4.97–11.50) | 64 | 189,628 | 7.67 (3.65–16.09) | 7.59 (5.27–10.93) |
| AP (95% CI) | 0.28 (0.05–0.52) | 0.29 (0.00–0.59) | 0.29 (0.10–0.47) | |||||
| BMI ≥ 25 | TCF7L2 TT/TC | |||||||
| – | − | 58 | 756 | 1 (Reference) | 18 | 241,094 | 1 (Reference) | 1 (Reference) |
| + | − | 121 | 672 | 1.91 (1.34–2.73) | 55 | 251,403 | 2.10 (1.22–3.61) | 1.97 (1.46–2.65) |
| – | + | 55 | 631 | 1.19 (0.79–1.80) | 5 | 196,969 | 0.34 (0.13–0.91) | 0.43 (0.36–0.51) |
| + | + | 137 | 576 | 2.67 (1.88–3.79) | 53 | 196,654 | 2.60 (1.51–4.47) | 2.65 (1.97–3.56) |
| AP (95% CI) | 0.21 (–0.07 to 0.49) | 0.45 (0.11–0.78) | 0.31 (0.09–0.52) | |||||
| BMI ≥ 25 | FTO AA/AT | |||||||
| – | − | 47 | 475 | 1 (Reference) | 9 | 156,631 | 1 (Reference) | 1 (Reference) |
| + | − | 78 | 387 | 1.61 (1.06–2.44) | 22 | 144,128 | 1.91 (0.87–4.16) | 1.67 (1.16–2.42) |
| – | + | 66 | 794 | 0.80 (0.53–1.22) | 14 | 281,432 | 0.87 (0.38–2.02) | 0.81 (0.56–1.18) |
| + | + | 180 | 761 | 1.93 (1.33–2.79) | 86 | 303,929 | 3.58 (1.79–7.15) | 2.21 (1.60–3.07) |
| AP (95% CI) | 0.27 (–0.06 to 0.59) | 0.50 (0.17–0.83) | 0.38 (0.15–0.61) | |||||
Adjusted for age, sex, smoking, and physical activity. HLA high risk: DR4/4, DR3/3, DR3/4, DR3/4–DQ8, DR4/4–DQ8 or DR4/X–DQ8.