Table 3.
RRs and APs Due to Interaction With 95% CIs in Relation to Type 2 Diabetes for Different Combinations of BMI and Genotypes of HLA, TCF7L2, and FTO
| BMI Categories | Genotypes | ESTRID | HUNT | Pooled | ||||
|---|---|---|---|---|---|---|---|---|
| Cases (n) | Controls (n) | RR (95% CI) | Cases (n) | Person-Years | RR (95% CI | RR (95% CI) | ||
| BMI ≥ 25 | HLA high risk | |||||||
| − | − | 57 | 637 | 1 (Reference) | 124 | 251,825 | 1 (Reference) | 1 (Reference) |
| + | − | 825 | 587 | 16.49 (11.42–23.81) | 1004 | 258,428 | 5.61 (4.65–6.77) | 7.01 (5.93–8.29) |
| − | + | 27 | 325 | 1.48 (0.85–2.58) | 98 | 186,239 | 1.06 (0.82–1.39) | 1.13 (0.89–1.43) |
| + | + | 376 | 277 | 15.51 (10.50–22.90) | 675 | 189,628 | 5.16 (4.25–6.26) | 6.42 (5.39–7.63) |
| AP (95% CI) | –0.09 (–0.34 to –0.15) | –0.10 (–0.22 to 0.02) | –0.10 (–0.21 to 0.01) | |||||
| BMI ≥ 25 | TCF7L2 TT/TC | |||||||
| − | − | 40 | 756 | 1 (Reference) | 95 | 241,094 | 1 (Reference) | 1 (Reference) |
| + | − | 556 | 672 | 14.73 (10.01–21.68) | 763 | 251,403 | 5.46 (4.40–6.77) | 6.91 (5.72–8.34) |
| − | + | 43 | 631 | 1.64 (1.00–2.70) | 127 | 196,969 | 1.63 (1.25–2.12) | 1.63 (1.29–2.06) |
| + | + | 606 | 576 | 18.78 (12.74–27.69) | 916 | 196,654 | 8.43 (6.82–10.43) | 10.14 (8.42–12.22) |
| AP (95% CI) | 0.18 (0.03–0.33) | 0.28 (0.20–0.36) | 0.26 (0.19–0.33) | |||||
| BMI ≥ 25 | FTO AA/AT | |||||||
| − | − | 30 | 475 | 1 (Reference) | 76 | 156,631 | 1 (Reference) | 1 (Reference) |
| + | − | 375 | 387 | 12.52 (8.01–19.58) | 510 | 144,128 | 5.23 (4.10–6.66) | 6.38 (5.15–7.90) |
| − | + | 53 | 794 | 1.07 (0.64–1.79) | 146 | 281,432 | 1.08 (0.82–1.43) | 1.08 (0.84–1.38) |
| + | + | 787 | 761 | 14.23 (9.24–21.92) | 1169 | 303,929 | 5.72 (4.53–7.22) | 7.13 (5.77–8.82) |
| AP (95% CI) | 0.12 (–0.06 to 0.29) | 0.07 (–0.04 to 0.18) | 0.08 (–0.01 to –0.18) | |||||
Adjusted for age, sex, smoking and physical activity. HLA high risk: DR4/4, DR3/3, DR3/4, DR3/4–DQ8, DR4/4–DQ8 or DR4/X–DQ8.