Table 3.
Characteristics of Participants Without PA Who Had Positive AARR at Baseline or Positive SIT Result
| Variable | Positive AARR and No PA (n = 38) | Positive SIT Result and No PA (n = 8) |
| Age, y | 58.6 ± 11.6 | 42.9 ± 13.6 |
| Women, % | 60.5 | 25.0 |
| BMI, kg/m2 | 27.3 ± 4.1 | 31.1 ± 6.4 |
| Systolic blood pressure, mm Hg | 162 ± 25 | 153 ± 27 |
| Diastolic blood pressure, mm Hg | 96 ± 12 | 95 ± 11 |
| Aldosterone, ng/dL | 19.5 (15.3–24.6) | 26.1 (17.4–32.5) |
| Renin, µU/mL | 3.4 (2.3–4.2) | 17.7 (7.2–41.0) |
| Baseline AARR, ng/dL/µU/mL | 5.63 (4.53–7.42) | 1.42 (0.66–2.59) |
| Second AARR, ng/dL/µU/mL | 5.59 (3.06–9.23) | 1.01 (0.31–2.04) |
| Aldosterone after SIT, ng/dL | 5.7 (4.6–7.4) | 11.2 (10.2–11.9) |
| Serum potassium, mmol/L | 3.8 ± 0.3 | 3.8 ± 0.5 |
| Serum potassium < 3.5 mmol/L, % | 10.5 | 25.0 |
| Serum sodium, mmol/L | 142 ± 2 | 142 ± 3 |
| Creatinine, mg/dL | 0.93 ± 0.21 | 0.94 ± 0.16 |
| GFR-MDRD, mL/min/1.73 m2 | 73.8 ± 15.7 | 82.8 ± 14.4 |
| PTH, pg/mL | 48.2 ± 14.8 | 50.2 ± 11.4 |
| Fasting glucose, mg/dL | 90 (82–106) | 91 (84–104) |
| HbA1c, mmol/mol | 37 (35–38) | 34 (31–47) |
| HDL cholesterol, mg/dL | 59 ± 13 | 56 ± 26 |
| LDL cholesterol, mg/dL | 122 ± 30 | 111 ± 30 |
| Triglycerides, mg/dL | 103 (81–159) | 121 (81–165) |
| C-reactive protein, mg/dL | 1.7 (1.0–3.1) | 3.4 (1.3–26.4) |
| No. of antihypertensive drugs | 3 (1–4) | 3 (1–4) |
| ACE inhibitors, % | 23.7 | 37.5 |
| Angiotensin-2–receptor blockers, % | 34.2 | 25.0 |
| Calcium-channel blockers, % | 52.6 | 50.0 |
| β-blockers, % | 68.4 | 37.5 |
| Diuretics, % | 34.2 | 62.5 |
| Thiazide diuretics, % | 39.5 | 50.0 |
| Loop diuretics, % | 0 | 12.5 |
| NSAIDs, % | 18.4 | 0 |
Continuous data are presented as mean ± SD or as median with interquartile range. Categorical data are presented as percentages. PA was diagnosed in patients with a positive AARR and a positive SIT result, whereas PA was excluded if results of only one or none of these two tests were positive.
Abbreviations: ACE, angiotensin-converting enzyme; BMI, body mass index; GFR-MDRD, glomerular filtration rate calculated according to the Modification of Diet in Renal Disease criteria; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NSAID, nonsteroidal anti-inflammatory drug.