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. 2019 Aug 25;5(3):dvz015. doi: 10.1093/eep/dvz015

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8: — significant overlap of methylated loci caused by aging and SL feeding. (a) Numbers of loci that show increased/decreased DNA methylation from P21 to P180, and those showing higher methylation in SL islets at P21. Out of 790 P21 SL > C loci, 401 also gain DNA methylation with aging (P < 0.0001 with χ² test). (b) All 401 overlapping loci were plotted according to their MSA-seq read numbers from P21 to P180 in C (left) and SL islets (right). An obvious trend of increasing DNA methylation can be seen only in C islets.