. 2019 Jun 20;104(10):4501–4510. doi: 10.1210/jc.2019-00843

Table 3.

Skeletal Variables in Premenopausal Women

Variable	Amenorrheic Women With AN (n = 27)	Eumenorrheic Women With AN (n = 10)	Lean HC (n = 29)	Overall P Value
Estimated strength by HRpQCT
Radial failure load, N	2998.48 ± 667.14^a	3344 ± 588.76^a	3863.29 ± 636.52^b	<0.0001
Tibial failure load, N	8255.33 ± 1774.88^a	9000 ± 1176.72^a	10804.28 ± 1483.18^b	<0.0001
Individual trabeculae segmentation measurements
Radius
Bone volume fraction	0.22 ± 0.05^a	0.26 ± 0.04^b	0.27 ± 0.04^b	0.0001
Plate bone volume fraction	0.07 ± 0.03^a	0.09 ± 0.04^a^,^b	0.11 ± 0.04^b	0.004
Rod bone volume fraction	0.15 ± 0.03^a	0.17 ± 0.02^b	0.17 ± 0.02^b	0.03
Axial bone volume fraction	0.09 ± 0.03^a	0.10 ± 0.03^a^,^b	0.11 ± 0.03^b	0.01
Plate number density, mm⁻¹	1.29 ± 0.16^a	1.41 ± 0.17^a	1.46 ± 0.15^b	0.002
Rod number density, mm⁻¹	1.78 ± 0.18^a	1.88 ± 0.10^a^,^b	1.88 ± 0.12^b	0.03
Plate-plate junction density, mm⁻³	1.48 ± 0.47^a	1.92 ± 0.63^b	2.08 ± 0.60^b	0.001
Plate-rod junction density, mm⁻³	3.07 ± 0.75^a	3.91 ± 0.98^b	4.10 ± 0.91^b	0.0005
Rod-rod junction density, mm⁻³	2.65 ± 0.78	3.01 ± 0.62	2.97 ± 0.71	0.15
Plate-to-rod ratio	0.51 ± 0.27	0.56 ± 0.23	0.67 ± 0.35	0.09
Tibia
Bone volume fraction	0.24 ± 0.06^a	0.26 ± 0.03^a^,^b	0.29 ± 0.04^b	0.0007
Plate bone volume fraction	0.11 ± 0.05^a	0.13 ± 0.02^a^,^b	0.15 ± 0.04^b	0.01
Rod bone volume fraction	0.12 ± 0.03	0.13 ± 0.02	0.14 ± 0.03	0.06
Axial bone volume fraction	0.12 ± 0.04^a	0.13 ± 0.02^a^,^b	0.14 ± 0.03^b	0.01
Plate number density, mm⁻¹	1.42 ± 0.18^a	1.49 ± 0.09^a^,^b	1.56 ± 0.12^b	0.002
Rod number density, mm⁻¹	1.67 ± 0.18	1.69 ± 0.12	1.76 ± 0.17	0.13
Plate-plate junction density, mm⁻³	1.86 ± 0.59^a	2.10 ± 0.37^a^,^b	2.42 ± 0.54^b	0.001
Plate-rod junction density, mm⁻³	3.22 ± 0.88^a	3.61 ± 0.74^a^,^b	4.13 ± 1.06^b	0.002
Rod-rod junction density, mm⁻³	2.04 ± 0.79	2.03 ± 0.47	2.31 ± 0.82	0.36
Plate-to-rod ratio	1.02 ± 0.52	1.02 ± 0.23	1.15 ± 0.57	0.47

Data are presented as mean ± SD.

Abbreviation: N, Newtons.

^{^a}

Groups with different superscripts differ significantly at P ≤ 0.05.

^{^b}

Groups with different superscripts differ significantly at P ≤ 0.05.