Figure 1.

Sensing of FV and induction of intrinsic and innate immunity. After virus entry, a number of different viral nucleic acid products can be sensed and IFN I responses are initiated. Although the IFN I response is limited by FV due to an unknown viral mechanisms, it induces the expression and activity of the restriction factors APOBEC3 and Tetherin as well as anti-viral NK cell responses. Complement binding can directly lead to virus lysis or increase virus uptake leading to cellular degradation and improved antigen presentation.