Figure 3.

Multifactorially adjusted hazard ratios for all-cause mortality according to plasma levels of apolipoprotein E in individuals in the general population. Solid lines are multifactorially adjusted hazard ratios, whereas dashed lines indicate 95% confidence intervals derived from restricted cubic splines with three knots and with the reference defined as the plasma level of apolipoprotein E with lowest overall mortality (4.5 mg/dL). Graphs are truncated at the level of 2.1 mg/dL and 7.1 mg/dL, due to statistically unstable estimates at extreme low and high levels thus only including 98 350 individuals from the Copenhagen General Population Study and the Copenhagen City Heart Study in these analyses (56 264 in the ɛ33 genotype stratified analyses). Cox regression models were adjusted for age (time scale), sex, body mass index, smoking, hypertension, diabetes, lipid-lowering therapy, alcohol consumption, physical inactivity, education, postmenopausal status, hormonal replacement therapy, LDL cholesterol, HDL cholesterol, and plasma triglycerides (both panels), and further adjustment for APOE genotype in the upper panel while analyses were restricted to ɛ33 carriers in bottom panels. 95% CI, 95% confidence interval; APOE, APOE ɛ2/ɛ3/ɛ4 genotype; ɛ33, APOE wildtype carriers.