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. 2019 Jun 24;40(33):2813–2824. doi: 10.1093/eurheartj/ehz402

Figure 5.

Figure 5

Multifactorially adjusted hazard ratios for all-cause and cause-specific mortality for septiles of apolipoprotein E in individuals in the general population. Cox regression models were multifactorially adjusted for age (time scale), sex, body mass index, smoking, hypertension, diabetes, lipid-lowering therapy, alcohol consumption, physical inactivity, education, postmenopausal status, hormonal replacement therapy, LDL cholesterol, HDL cholesterol, triglycerides (all panels), with further adjustment for APOE genotype (upper panels) and in analyses restricted to ɛ33 carriers (bottom panels). For cause-specific mortality, there are three parallel analyses: when Bonferroni-correction is applied (P = 0.05/3 = 0.02), results for the first septile of apoE for dementia-associated mortality does not adhere to this significance level (P = 0.04) and likewise for the second septile for cardiovascular mortality (P = 0.03). All other results are unaffected. 95% CI, 95% confidence interval; apoE, plasma apolipoprotein E level; APOE, APOE ɛ2/ɛ3/ɛ4 genotype; ɛ33, APOE wildtype carriers.