Table 2.

Baseline characteristics for women and men in the general population with low and high plasma apolipoprotein E

Characteristic	Plasma apolipoprotein E
	Women			Men
	≤4.5 mg/dL	>4.5 mg/dL	P-valuea	≤4.5 mg/dL	>4.5 mg/dL	P-valuea
Individuals, N	35 087	22 314	—b	31 936	14 816	5 × 10−128 b
Age (years)	55.0 ± 0.1	61.2 ± 0.1	<1 × 10−300	57.9 ± 0.1	58.3 ± 0.1	0.13
Body mass index (kg/m2)	25.0 ± 0.0	26.4 ± 0.0	8 × 10−282	26.4 ± 0.0	27.6 ± 0.0	3 × 10−240
Hypertension (%)	48	63	5 × 10−270	64	72	3 × 10−60
Diabetes mellitus (%)	3	3	0.01	5	5	1 × 10−4
Smoking (%)	20	19	0.02	21	23	0.003
High alcohol consumption (%)	13	16	2 × 10−13	19	24	9 × 10−29
Physical inactivity (%)	53	57	3 × 10−22	43	50	2 × 10−36
Postmenopausal (%)c	59	80	<1 × 10−300	—	—	—
Hormonal replacement therapy (%)c	11	10	0.01	—	—	—
Lipid-lowering therapy (%)	10	8	6 × 10−20	15	8	4 × 10−106
Education<8 years (%)	10	15	9 × 10−88	13	14	0.001
APOE genotype (%)			<1 × 10−300			<1 × 10−300
ɛ22	0	2		0	2
ɛ32	4	26		4	30
ɛ33	57	53		60	47
ɛ42	1	6		1	6
ɛ43	34	13		31	14
ɛ44	5	1		3	1

Values are presented as number, mean ± standard error of the mean, or percentage and are from the day of enrolment (2003–13 for the Copenhagen General Population Study and 1991–94 or 2001–03 for the Copenhagen City Heart Study). Missing data and definitions of variables were identical to the descriptions given in the legend to Table 1.

^a P for differences by the Kruskal–Wallis equality-of-populations rank test or by the Pearson’s χ² test, as appropriate.

^bOne test for men and women with low and high apoE.

^cIn women only.