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. 2019 Aug 2;47(15):7809–7824. doi: 10.1093/nar/gkz672

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Indirect binding of the 100 TFs analyzed in the K562 cell line. The names of the 100 TFs are indicated around the inner circle, and a ribbon connects two TFs which have predicted tethering binding association. The thickness of the ribbon is proportional to the ratio of peaks, linking wide-sided -TF’s (indirect) with the narrow-sided -TF’s (direct). The blue bar and red bar in the outer circle indicate the ratio of and the ratio of (indecipherable—cannot be resolved as tethering/binding) in each TF’s ChIP-Seq dataset, respectively. Four examples of tethering binding association are showcased around the outer circle, each of which indicates that one TF (lavender ball) interacts with DNA by binding to another DNA-binding TF (orange ball).

Inline graphic — Indirect binding of the 100 TFs analyzed in the K562 cell line. The names of the 100 TFs are indicated around the inner circle, and a ribbon connects two TFs which have predicted tethering binding association. The thickness of the ribbon is proportional to the ratio of peaks, linking wide-sided -TF’s (indirect) with the narrow-sided -TF’s (direct). The blue bar and red bar in the outer circle indicate the ratio of and the ratio of (indecipherable—cannot be resolved as tethering/binding) in each TF’s ChIP-Seq dataset, respectively. Four examples of tethering binding association are showcased around the outer circle, each of which indicates that one TF (lavender ball) interacts with DNA by binding to another DNA-binding TF (orange ball).