Figure 1.

DAXX structure and interacting proteins. The modular structure arrangement of DAXX is depicted. SIM: SUMO-interacting motif, 4HB: DAXX helix bundle, HBD: histone-binding domain, NLS: nuclear localization signal. Proteins that are known to interact with specific regions of DAXX are shown. The 4HB is probably the major binding site for proteins that interact with the DAXX N-terminal region, while SIM2 likely plays a major role in binding proteins that interact with the DAXX C-terminal region. The lines below or above each protein group are not meant to be precise. Readers are referred to the original publications reporting a specific interaction (see Table 1).