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. 2019 Jul 3;47(15):8255–8271. doi: 10.1093/nar/gkz564

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 11. — A proposed model for satRNA inhibiting the accumulation of CMV RNAs. RNAs 1 and 2 released from infected CMV are used as translation templates to produce viral replicase components 1a and 2a, respectively. Differential host factors are subsequently recruited by viral replicase and RNAs to form replication machinery for replication of RNAs 1 and 2 or RNA3. CMV satRNAs specifically compete the replication machinery for replication of RNAs 1 and 2, by which it reduces the accumulation of both viral RNAs. Once the accumulation of RNAs 1 and 2 is reduced to a level at which the 1a and 2a proteins produced by both viral RNAs become limited for RNA3 replication, the accumulation of RNA3 is reduced as observed in the case of sat-SD shown in this study.