Figure 5.

Schematic of activation-dependent looping events in HO-1 locus in SIRT6 wild type and knock out tissue. A schematic diagram based on the looping events shown in Figure 4, assuming that all looping events can occur in a single cell. In this model, all small loops converge on a common core base bound to BAF complex (green spheres) in a SIRT6- and mono-ADP ribosylation-dependent manner. As a consequence, the total physical volume of the active transcriptional complex is reduced, enhancing the accessibility of factors to genomic sites in a single transcriptionally active domain (60). HO-1 gene is highlighted in black.