Table 1.
Mean (SEM) Volume of the GCL and Hilus and BrdU Density in Hilus in Gonadectomized Young and Middle-Aged Male and Female Rats Treated With Oil or DHT
| Age, Sex, and Treatment | Sample Size, n | GCL Volume, mm3 | Hilus Volume, mm3 | Hilus BrdU Density, per mm3 |
|---|---|---|---|---|
| Young | ||||
| Females | ||||
| Oil | 7 | 2.51 (0.12) | 6.09 (0.19) | 85.14 (15.34) |
| DHT | 8 | 2.46 (0.08) | 6.00 (0.28) | 76.06 (7.06) |
| Males | ||||
| Oil | 5 | 2.31 (0.19) | 5.32 (0.49) | 96.18 (23.29) |
| DHT | 6 | 2.62 (0.21) | 5.37 (0.51) | 134.70 (17.38) |
| Middle age | ||||
| Females | ||||
| Oil | 6 | 2.33 (0.09) | 7.67 (0.42) | 20.69 (7.89) |
| DHT | 6 | 2.45 (0.15) | 7.33 (0.28) | 6.40 (2.49) |
| Males | ||||
| Oil | 6 | 2.94 (0.25) | 9.05 (0.79) | 6.06 (1.41) |
| DHT | 6 | 2.87 (0.22) | 10.05 (0.60) | 4.65 (1.63) |
The volume of the hilus was larger than the volume of the GCL (main effect of region; P < 0.0001). Males had a larger volume of GCL and hilus than females (main effect of sex; P < 0.05). The volume of the GCL and hilus increased with age (main effect of age; P < 0.0001) and in the hilus, the volume increased with aging more so in males than females (interaction between region, age, and sex; P < 0.0001). DHT treatment did not affect the volume of the GCL and hilus (all P > 0.08). The density of BrdU+ cells was not significantly affected by age, sex, or treatment (all P > 0.9). Sample size is number of individuals.