Table 2.
Mean (SEM) Percentage of Cells Coexpressing BrdU and NeuN in GCL in Gonadectomized Young and Middle-Aged Male and Female Rats Treated With Oil or DHT
| Age, Sex, and Treatment | Sample Size, n | BrdU/NeuN, % |
|---|---|---|
| Young | ||
| Females | ||
| Oil | 5 | 87.89 (2.27) |
| DHT | 8 | 87.16 (1.10) |
| Males | ||
| Oil | 4 | 88.68 (1.94) |
| DHT | 5 | 84.24 (3.12) |
| Middle age | ||
| Females | ||
| Oil | 6 | 63.80 (3.43) |
| DHT | 6 | 81.32 (5.82)a |
| Males | ||
| Oil | 6 | 67.03 (5.39) |
| DHT | 6 | 70.88 (7.00) |
The proportion of BrdU+ cells colabeled with NeuN was significantly higher in young compared with middle-aged animals (main effect of age; P < 0.0001). In middle-age, but not in young adults, DHT increased the proportion of BrdU/NeuN colabeled cells relative to the oil treatment group (interaction between age and treatment), but this effect was driven by the middle-aged females (P = 0.005) compared with the middle-aged males (P = 0.48). Sample size is number of individuals.
a
P < 0.01 relative to oil treatment group.