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. 2019 Aug 1;11(8):2420–2438. doi: 10.1093/gbe/evz162

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 4. — —Toxin–antitoxin content of mycobacterial species in the MTBAP lineage and other SGM. (A) Number of putative toxin genes bearing PIN and MazF domain in SGM. Toxins from toxin–antitoxin systems were identified from whole proteome data sets, using HMMER (PF02452.16—PemK_toxin; PF01850.20 PIN domain) with a 0.01 threshold e value. Orange: VapC. Blue MazF. **: Values above two standard deviation levels from SGM (outside MTBAP lineage and MGS–MKM outgroup) average. (B) Putative orthologs of M. tuberculosis VapC and MazF toxins. Yellow: BBH 50% translated sequence identity, BBH 80% query cover. Red: BBH and synteny. Mcan, M. canettii STB-K; Mdec, M. decipiens; Mshi, M. shinjukuense; Mlac, M. lacus; Mriy, M. riyadhense; Mkan, M. kansasii; Mmar, M. marinum E11; Mszu, M. szulgai; Mgor, M. gordonae.