TABLE 2.

Top genes associated with DGAI in combined sample of Framingham Heart Study Offspring and Third-Generation participants (n = 5161)¹

	Primary model				Secondary model2
Gene	β	SE	P value	FDR	β	SE	P value
ARRDC3	0.0016	0.0003	1.8 × 10−6	0.020	0.0011	0.0003	7.9 × 10−4
SIX4	0.0012	0.0003	3.1 × 10−6	0.020	0.0010	0.0003	1.3 × 10−4
PKN2	0.0011	0.0002	4.1 × 10−6	0.020	0.0008	0.0002	4.1 × 10−4
RNF141	0.0016	0.0003	4.5 × 10−6	0.020	0.0011	0.0003	1.7 × 10−3
NOLC1	−0.0013	0.0003	1.1 × 10−5	0.034	−0.0012	0.0003	1.1 × 10−4
STAG1	0.0008	0.0002	1.3 × 10−5	0.034	0.0006	0.0002	4.4 × 10−4
DNAJA1	−0.0012	0.0003	1.5 × 10−5	0.034	−0.0011	0.0003	1.8 × 10−4
MIER1	0.0010	0.0002	1.5 × 10−5	0.034	0.0009	0.0002	1.6 × 10−4
G0S2	0.0027	0.0006	1.7 × 10−5	0.034	0.0024	0.0006	2.1 × 10−4
PTP4A1	0.0012	0.0003	2.5 × 10−5	0.037	0.0009	0.0003	1.8 × 10−3
EXOC8	0.0010	0.0002	2.5 × 10−5	0.037	0.0008	0.0002	9.5 × 10−4
FAM116A	0.0010	0.0002	2.7 × 10−5	0.037	0.0009	0.0002	4.6 × 10−4
HIST1H2AE	0.0027	0.0007	2.7 × 10−5	0.037	0.0022	0.0007	1.0 × 10−3
IER3	0.0012	0.0003	3.1 × 10−5	0.039	0.0010	0.0003	7.5 × 10−4
SNX13	0.0010	0.0002	3.5 × 10−5	0.042	0.0008	0.0002	1.4 × 10−3
CYB5R4	0.0011	0.0003	4.8 × 10−5	0.050	0.0007	0.0003	4.5 × 10−3
RFWD2	0.0010	0.0003	5.0 × 10−5	0.050	0.0009	0.0003	2.3 × 10−4
CCDC126	0.0016	0.0004	5.3 × 10−5	0.050	0.0012	0.0004	4.0 × 10−3
HSPH1	−0.0013	0.0003	5.3 × 10−5	0.050	−0.0012	0.0003	2.1 × 10−4

¹Genes with FDR <0.05 are listed. The primary model was adjusted for age, sex, pack-years, imputed cell counts, and technical covariates. In comparison with the primary model, the secondary model was additionally adjusted for BMI, current smoking, hypertension, type 2 diabetes, total cholesterol, HDL cholesterol, lipid treatment, physical activity index, prevalent cardiovascular disease, and energy intake. DGAI, Dietary Guidelines for Americans Adherence Index; FDR, false discovery rate.