Fig. 1.

Overview of Deuteros demonstrated on the XylE transporter. Visualization of (a) experimental protein coverage, (b) data redundancy and (c) deuterium uptake differences in Woods plot format. Dashed and dotted lines indicate 98 and 99% confidence limits applied to the dataset to identify peptides with significant deuteration differences. Deprotected, protected and non-significantly different peptides are in red, blue and grey respectively. (d) Differential HDX-MS data for the wild-type and E153Q mutant XylE has been projected onto its crystal structure (PDB ID: 4GBY) (Color version of this figure is available at Bioinformatics online.)