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. 2019 Jun 18;101(2):445–456. doi: 10.1093/biolre/ioz108

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© The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

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Figure 8. — Proposed model for the effect of BMP6 on the expression levels CTGF and LOX in human granulosa-lutein cells. BMP6 binds to a complex containing type I (ALK2 and ALK3) and II receptors leading to the phosphorylation/activation of receptor-regulated SMAD (SMAD1/5/8), which binds to the common SMAD (SMAD4). This complex then translocates into the nucleus to promote the transcription of CTGF. The up-regulation of CTGF subsequently contributes to the increase in LOX expression in human granulosa-lutein cells.