TABLE 1.

Subjects’ characteristics¹

	Lean	Obese
Age, y	43 ± 3	48 ± 2
Weight, kg	76.5 ± 1.6	117.9 ± 6.5*
BMI, kg/m2	23.4 ± 0.4	37.0 ± 1.5*
Plasma glucose OGTT t = 0 min, mmol/L	5.2 ± 0.1	6.1 ± 0.2*
Plasma glucose OGTT t = 120 min, mmol/L	4.4 ± 0.3	6.8 ± 0.7*
Plasma insulin OGTT t = 0 min, pmol/L	61 ± 6	215 ± 19*
Plasma insulin OGTT t = 120 min, pmol/L	121 ± 17	756 ± 171*
Glycated hemoglobin, mmol/mol	33.7 ± 1.0	36.8 ± 1.0**
Oral glucose insulin sensitivity,2 mL · min−1 · m−2	451 ± 12	277 ± 19*
HOMA-IR2	1.14 ± 0.12	4.03 ± 0.34*
Postabsorptive plasma IL-6,3 pg/mL	0.68 ± 0.12	1.19 ± 0.20**
Postabsorptive plasma NEFA,3 μmol/L	390 ± 39	451 ± 45
Postabsorptive plasma TG,3 mmol/L	0.98 ± 0.16	1.81 ± 0.29*

¹Values are mean ± SEM, n = 12/group. Data were analyzed by unpaired Student's t test. *, **Different from lean: *P < 0.05, **P < 0.1. NEFA, nonesterified fatty acid; OGTT, oral-glucose-tolerance test; TG, triacylglycerol.

²Assessed by 2-h OGTT after consumption of 75 g glucose (28).

³Postabsorptive plasma IL-6, NEFA, and TG were analyzed during the experimental trial at t = −210 min.