Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 22;6(5):e1618174. doi: 10.1080/23723556.2019.1618174

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Taylor & Francis Group, LLC

PMC Copyright notice

Figure 1. — Neddylation dependent and independent activities of MLN4924. (1) Inactivating CRL (Cullin-RING ligase) E3: MLN4924 inactivates CRLs by blocking cullin neddylation to cause the accumulation of a number of tumor suppressor proteins, leading to growth suppression via inducing growth arrest, apoptosis, senescence, or autophagy in a variety of cancer cell lines. (2) Inducing EGFR (epidermal growth factor receptor) dimerization: MLN4924 activates EGFR by triggering its dimerization to activates its downstream RAS/MAPK pathway to promotes tumor sphere formation and wound healing, and PI3K/AKT1 pathway to inhibits ciliogenesis, respectively. (3) Inducing PKM2 (M2 isoform of pyruvate kinase) tetramerization: MLN4924 activates PKM2 via promoting its tetramerization to increase glycolysis.