Growth parameters and biochemical markers with medical and surgical intervention from 0 to 24 mo of age. (A) The infant’s height and weight, plotted on the WHO Growth Curve, increase over time despite medical and surgical intervention. (B) Serum concentrations of PRL [normal for age, 3.5 to 16 ng/mL (152 to 696 pmol/L)], GH [normal for age, ≤5 ng/mL (≤5 µg/L)], and IGF-1 [normal for age, 27 to 157 ng/mL (4 to 21 nmol/L)] are shown. The superimposed timeline indicates treatment with bromocriptine starting at 6 mo of age; hatch marks show increases in dosing and end at 15 mo of age at the time of surgical intervention.