Fig 1. Representative silver-stained two-dimensional electrophoresis (2-DE) images for serum samples from patients with prediabetes/diabetes compared with healthy donors.

(A) Differentially expressed spots are indicated with arrows (Red, up-regulated; Blue, down regulated) in the 2-DE image, (B) comparison of the regulatory patterns of serum proteins in the six groups. Group 1 = normal, Group 2 = normal with abdominal obesity, Group 3 = pre-diabetes, Group 4 = pre-diabetes with abdominal obesity, Group 5 = diabetes, Group 6 = diabetes with abdominal obesity. See Table 1 for patient details.