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. 2019 Aug 19;13(8):e0007623. doi: 10.1371/journal.pntd.0007623

Table 2. Association of helminth infections with percent of HLA-DRpos CD4 T cells.

Uni- and multi-variable mixed-effects linear regression results, with random effect for residence in Kyela site, multivariable results adjusted for all variables shown.

  univariable multivariable
Covariate N Mean Coef. 95% CI p-value Coef. 95% CI p-value
Age            
     (per year) - - 0,13 (0.08 to 0.18) 0.0000 0,14 (0.09 to 0.18) 0.0000
Sex            
    female* 131 8,78 0,00 - - 0,00 - -
    male 95 8,45 -0,56 (-1.71 to 0.58) 0.3332 0,15 (-0.92 to 1.21) 0.7887
Current fever            
    no* 200 8,50 0,00 - - 0,00 - -
    yes 20 10,39 1,99 (0.04 to 3.95) 0.0460 1,36 (-0.45 to 3.18) 0.1412
    no data 6 7,39 -0,48 (-3.96 to 3.00) 0.7860 -0,13 (-3.35 to 3.09) 0.9359
W. bancrofti            
    neg. * 193 8,31 0,00 - - 0,00 - -
    pos. 33 10,59 1,83 (0.14 to 3.52) 0.0337 1,58 (0.08 to 3.09) 0.0392
Hookworm            
    neg. * 147 8,83 0,00 - - 0,00 - -
    pos. 79 8,29 -0,62 (-1.79 to 0.55) 0.3019 -0,74 (-1.83 to 0.35) 0.1827
A. lumbricoides            
    neg. * 177 8,25 0,00 - - 0,00 - -
    pos. 49 10,05 1,49 (0.11 to 2.86) 0.0337 2,12 (0.80 to 3.43) 0.0016
T. trichiura            
    neg. * 189 8,34 0,00 - - 0,00 - -
    pos. 37 10,15 1,15 (-0.53 to 2.83) 0.1807 1,82 (0.34 to 3.31) 0.0162
S. mansoni            
    neg. * 145 8,64 0,00 - - 0,00 - -
    pos. 81 8,63 -0,09 (-1.26 to 1.08) 0.8839 1,46 (0.28 to 2.65) 0.0155
S. haematobium            
    neg. * 209 8,67 0,00 - - 0,00 - -
    pos. 17 8,22 -0,48 (-2.60 to 1.64) 0.6573 0,71 (-1.26 to 2.67) 0.4818

N = number of observations; Mean = mean outcome; Coef. = coefficient; 95% CI = 95% confidence interval

* reference stratum