. 2019 Aug 22;11(7):615–619. doi: 10.1093/jmcb/mjz063

Table 1.

p53 restoration models.

Genotype	p53 loss/restoration	Tumors	Effects on tumor growth	Cellular response	Reference
p53^LSL/LSL;Cre-ER^T2	Germline	Lymphomas	Regression	Apoptosis	Ventura et al. (2007)
p53^LSL/LSL;Cre-ER^T2	Germline	Sarcomas	Regression; stasis	Cell cycle arrest; senescence	Ventura et al. (2007)
p53^Neo/−;CAG-CreER	Germline	Lymphomas	Regression	Apoptosis	Wang et al. (2011)
p53^Neo/−;CAG-CreER	Germline	Angiosarcomas	Regression	Senescence	Wang et al. (2011)
p53^Neo/R172H;CAG-CreER	Germline	Lymphomas	Stasis	Apoptosis; senescence	Wang et al. (2011)
p53^Neo/R172H;CAG-CreER	Germline	Angiosarcomas	Stasis	Senescence; decreased cell proliferation	Wang et al. (2011)
p53^Neo/R172H;Cre-ER^T2	Germline	Lymphomas	Mixed	Apoptosis	Larsson et al. (2018)
HaRas^V12;p53 shRNA	Carcinoma only	Hepatocellular carcinomas	Regression	Senescence; immune response	Xue et al. (2007)
Eμ-myc;p53ER^TAM/+	B-cells	B-cell lymphomas	Delay	Apoptosis	Martins et al. (2006)
Mdm2Tg;p53^Neo/Neo;CAG-CreER	Germline	Angiosarcomas	Stasis	Decreased proliferation; senescence	Li et al. (2014)