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. 2019 Sep 4;6(9):ofz314. doi: 10.1093/ofid/ofz314

Figure 3.

Figure 3.

Parasite clearance times (A) and parasite clearance half-life (B) in Northern (Anlong Veng) and Eastern (Kratie) Cambodia by treatment regimen. All patients with treatment failure assigned to ASAP had a parasite clearance half-life (PCT1/2) >5 hours. Red dots represent parasite recrudescence based on genotyping with msp1, msp2, and glurp polymorphisms. Clear dots represent parasites with the K13 propeller C580Y mutation, green dots represent K13 wild-type parasites, and blue dots represent K13 propeller status unknown. The orange error bars represent medians and interquartile ranges for the variables presented. Comparison of parasite clearance time by t test with Mann-Whitney test revealed significantly faster parasite clearance time for the ASAP treatment vs AP in Eastern Cambodia only (P = .04). There were no significant differences in parasite clearance half-life overall. The median PCT1/2 was significantly higher at 5.34 nM for parasites with the K13 propeller C580Y mutation vs 3.42 for parasites without C580Y (P = .0032).