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. 2019 Jun 7;171(1):221–234. doi: 10.1093/toxsci/kfz136

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Figure 5. — Concentration-dependent effects of BDE-47 on global gene expression in NPCs. A, Genes identified to be DE due to BDE-47 exposure (589 total; ANOVA; p < .01, abs FC > 1.5). Expression profiles display patterns in expression with 1 or 10 µM (as compared with the respective vehicle control) across the 3 independent experiments. Clusters I and II indicated up and downregulated clusters of DE genes. Within this DE subset, we performed post hoc analyses for significance (t test) between vehicle and 1 or 10 µM BDE-47. B, Distribution of genes DE by each concentration. C, The top 25 most up (left) and down (right) regulated genes due to BDE-47 exposure.