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. 2019 Apr;60(5):1442–1453. doi: 10.1167/iovs.19-26560

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Copyright 2019 The Authors

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Summary of light-damage susceptibility in mouse strains used in this study. All mice were exposed to BLE at 12.5 klux light for 0.5 hours, and ONL thickness was determined from OCT images 7 days after BLE (Gnat2^−/−, n = 3; Gnat1^+/+, n = 13; Gnat1^−/−, n = 8; BALB/c, n = 8; Arr1^−/−, n = 8; Grk1^−/−, n = 6). The retinas were processed as flat mounts 8 days from BLE and stained against opsin antibodies. Cone-area preservation was evaluated from panoramic retina images (Gnat2^−/−, n = 3; Gnat1^+/+, n = 7; Gnat1^−/−, n = 4; BALB/c, n = 9; Arr1^−/−, n = 7; Grk1^−/−, n = 7). One-sample t-test was used to test if ONL thickness or preserved cone area was significantly different from 100% (baseline). Significance denoted by *P < 0.05, **P < 0.01, *P < 0.001.