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. 2019 Jun 14;171(1):32–45. doi: 10.1093/toxsci/kfz139

Figure 4.

Figure 4.

Venn diagrams of genes commonly or uniquely expressed in neonatal brains exposed in utero to BAC C12 or BAC C16: (A) upregulated genes or (B) downregulated genes. BAC C12 exposure led to an upregulation of 308 genes, whereas BAC C16 upregulated 65 genes. Of the genes with increased expression, 46 were coregulated by the BACs. BAC C12 exposure also led to a downregulation of 199 genes, whereas BAC C16 upregulated 74 genes. Of the genes with decreased expression, 31 were coregulated by the BACs. C, Top 5 canonical signaling pathways significantly altered in neonatal brains exposed in utero to BAC C12 or BAC C16. The BACs altered many of the same pathways, however TR/RXR activation was unique to BAC C12 and EIF2 signaling was unique to BAC C16. Z-score activation values to right of bar for each pathway, positive number indicates activation whereas negative number indicates inhibition of pathway. n = 4 biological replicates per condition; adjusted p < .05. Abbreviations: BAC, benzalkonium chloride; LXR/RXR, liver X receptor-retinoid X receptor; TR/RXR, thyroid hormone receptor-retinoid X receptor.